Hyalurinodase 1500 g unit

HYALURONIDASE Indications for Use

Hyaluronidase is an enzyme used specifically to dissolve hyaluronic acid polymers. It is widely utilized in aesthetic medicine to correct issues such as over-correction from hyaluronic acid fillers, fibrosis, and granulomas, as well as to manage vascular complications, which can lead to skin necrosis.

• Common Applications: Overcorrection of dermal fillers, granulomas, fibrosis, and vascular compression.
• Key Functions: Dissolving excess hyaluronic acid to restore balance and reduce risks associated with over-injections.

HYALURONIDASE Dosage Information

Hyaluronidase is generally supplied in a lyophilized powder form that must be reconstituted with sterile saline solution. It is typically provided in units of 1500 IU.

• Reconstitution: 1500 IU mixed with 8-10 ml saline solution.
• Injection Volume: Usually, 0.1 ml of the diluted solution is injected subcutaneously into the affected area.

HYALURONIDASE Side Effects and Precautions

The use of hyaluronidase comes with potential risks, particularly allergic reactions, since it is an exogenous enzyme. Reactions can be immediate (such as anaphylactic shock) or delayed by a few hours to days.

• Common Side Effects: Itching, redness, swelling at the injection site.
• Serious Risks: Immediate anaphylactic shock, general urticaria, respiratory distress, and hypotension.
• Precautionary Measures: Always perform an allergy test before administering hyaluronidase to prevent severe allergic reactions.

HYALURONIDASE Clinical Studies and Real-World Outcomes

Clinical evidence demonstrates that hyaluronidase effectively reduces excess hyaluronic acid or granulomas, delivering fast and definitive results. Reports show its success even in dissolving fillers that were injected years earlier. For cases involving vascular compression, hyaluronidase can mitigate the risk of skin necrosis if injected early.

• Results: Visible improvements can occur within 1 hour after injection.
• Necrosis Prevention: Early injections (within 24 hours) significantly reduce the likelihood of skin necrosis from vascular compression.

HYALURONIDASE Drug Interactions

Hyaluronidase is specific to hyaluronic acid and cannot dissolve other types of filler materials such as polylactic acid, collagen, or silicone. It interacts only with the bonds in hyaluronic acid, making it ineffective for treating reactions to other filler substances.

HYALURONIDASE Product Information

• Format: Available as lyophilized powder, typically 1500 IU per vial.
• Storage: Must be reconstituted immediately before use and injected promptly.
• Function: Hyaluronidase hydrolyzes the links between N-acetyl-D-glucosamine and D-glucuronic acid, breaking down the hyaluronic acid polymer into smaller oligomers that are no longer recognized as foreign by the immune system.

In conclusion, hyaluronidase is a vital tool in aesthetic medicine for managing complications from hyaluronic acid fillers, offering fast-acting and reliable results. However, proper precautionary testing is essential due to the risk of allergic reactions.